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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SREBF1
All Species:
14.24
Human Site:
S376
Identified Species:
31.33
UniProt:
P36956
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P36956
NP_001005291.1
1147
121675
S376
Y
I
R
F
L
Q
H
S
N
Q
K
L
K
Q
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001095392
1006
107600
H337
P
E
Q
R
P
S
P
H
S
R
G
M
L
D
R
Dog
Lupus familis
XP_536664
1152
121533
S377
Y
I
R
F
L
Q
Q
S
N
Q
K
L
K
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTN3
1134
120518
S370
Y
I
R
F
L
Q
H
S
N
Q
K
L
K
Q
E
Rat
Rattus norvegicus
P56720
1134
120502
S370
Y
I
R
F
L
Q
H
S
N
Q
K
L
K
Q
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510556
1117
119248
K367
K
Q
E
N
L
S
L
K
M
V
A
Q
K
N
K
Chicken
Gallus gallus
NP_989457
1115
118326
S372
M
A
V
Q
K
S
K
S
L
K
D
L
V
A
S
Frog
Xenopus laevis
Q6GQ26
1088
119806
D382
T
S
I
G
M
K
I
D
E
F
N
Q
N
A
L
Zebra Danio
Brachydanio rerio
A3KNA7
1099
120302
V373
Y
I
K
Y
L
Q
Q
V
N
H
K
L
R
Q
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_730449
1113
124436
R376
P
G
R
A
S
K
K
R
R
E
S
S
Q
T
F
Honey Bee
Apis mellifera
XP_396866
824
93228
L155
L
K
Q
E
N
M
S
L
K
L
A
Q
R
Q
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
83
88
N.A.
80.3
80.6
N.A.
67.8
63.1
42.2
37.4
N.A.
32
28.4
N.A.
N.A.
Protein Similarity:
100
N.A.
84.3
91
N.A.
86.1
86.5
N.A.
75.6
71.7
59.3
53.6
N.A.
46.9
43.5
N.A.
N.A.
P-Site Identity:
100
N.A.
0
93.3
N.A.
100
100
N.A.
13.3
13.3
0
60
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
N.A.
26.6
93.3
N.A.
100
100
N.A.
20
20
13.3
80
N.A.
26.6
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
10
0
0
0
0
0
0
19
0
0
19
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
10
0
0
10
0
% D
% Glu:
0
10
10
10
0
0
0
0
10
10
0
0
0
0
46
% E
% Phe:
0
0
0
37
0
0
0
0
0
10
0
0
0
0
10
% F
% Gly:
0
10
0
10
0
0
0
0
0
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
0
28
10
0
10
0
0
0
0
0
% H
% Ile:
0
46
10
0
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
10
0
10
19
19
10
10
10
46
0
46
0
10
% K
% Leu:
10
0
0
0
55
0
10
10
10
10
0
55
10
0
10
% L
% Met:
10
0
0
0
10
10
0
0
10
0
0
10
0
0
0
% M
% Asn:
0
0
0
10
10
0
0
0
46
0
10
0
10
10
10
% N
% Pro:
19
0
0
0
10
0
10
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
19
10
0
46
19
0
0
37
0
28
10
55
0
% Q
% Arg:
0
0
46
10
0
0
0
10
10
10
0
0
19
0
10
% R
% Ser:
0
10
0
0
10
28
10
46
10
0
10
10
0
0
10
% S
% Thr:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% T
% Val:
0
0
10
0
0
0
0
10
0
10
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
46
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _